Mrs. Winnifred Hoffman, age 59, died Monday, July 27, 1992.  She was a native and lifetime resident of San Antonio and was a member of the Gethsemane Lutheran Church.  Mrs. Hoffman is survived by her husband, Leroy Hoffman; sons, Roger Hoffman and wife, Lisa and Russell Hoffman; daughter, Rhonda Hoffman; sisters, Ruby Mangold and Lucille Bigley.  Funeral services will be held on Wednesday, July 29, 1992 at 10:00 A.M. at Gethsemane Lutheran Church 610 Avalon with Pastor Joel Flugstad officiating.  Interment will follow in Zion Lutheran Cemetery in Helotes.  In lieu of flowers, and if friends so desire, memorial contributions may be made to the Cancer Therapy and Research Center, 4450 Medical Dr. San Antonio, TX 78229.  Visitation for Mrs. Hoffman will be held from 7:00 P.M. until 9:00 P.M. Tuesday at the funeral home.  Arrangements are with: